Electrochemical C–H functionalization makes use of earth-abundant 3d metals and employs electricity as the oxidant, which makes the overall transformation economic and eco-friendly. Pd/photocatalyst merger can achieve the regioselective arylation of arenes and heteroarenes at room temperature. In this context, photoredox C–H arylation 6, 7 and electrochemical C–H arylation 8, 9 came up as other available options. Therefore, a sustainable approach was required to address such challenges. Transition-metal-catalyzed C–H arylation has been well explored over decades but suffers from major drawbacks viz harsh reaction conditions (elevated temperature, additives) and the use of expensive reagents, in turn diminishing the utility of such methodologies. Later on, various other methods for site-selective C–H functionalization were developed. Both aliphatic and aromatic C–H bonds were arylated with the help of a suitable directing group attached with the molecule 5. The problem of site selectivity has been addressed up to some extent with the help of directing group-assisted transition-metal-catalyzed C–H functionalization. However, controlling the site selectivity during C–H activation has always been a complicated issue to address. C–H arylation omits the use of pre-functionalized arenes, thus reflecting its superiority over cross-coupling strategies. In this context, direct C–H functionalization emerged as an efficient tool in the construction of C–C bonds. The use of pre-functionalized arenes sought to be one of the significant drawbacks of this methodology 4. Over the years, several modified versions of Suzuki coupling have been discovered 3. Suzuki coupling strategy demands a pre-functionalized (hetero)arenes as substrate and arylboronic acid as coupling partner. A study reveals that Suzuki coupling is the 2nd most utilized chemical transformation in medicinal chemistry to synthesize several drug molecules 2. One of such widespread cross-coupling reactions is Suzuki-Miyaura cross-coupling (Nobel Prize in 2010), which has been extensively studied by researchers in academia as well as in industry for synthesis of biaryls and hetero-biaryls 1. These methods are easy to perform, reliable, and quickly generate an assay of chemical space of different structural scaffolds. Over the last two decades, cross-coupling reactions have had a scintillating effect on medicinal chemistry, drug discovery, and agrochemicals, etc.
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